Allele-specific methylation
-p_AS
The proportion of allele-specific methylations. For example,
-p_AS 0.2
Approximately 20% of methylation blocks will have allele-specific methylations.
-r_methylated_father
Ratio of the father-specific methylation rate. Methylation rate for the paternal allele at a CpG will be r_methylated_father*p, where p is the methylation rate for the CpG from the profile.
For example,
-r_methylated_father 1.2
Assume p is 0.8. Methylation rate for the paternal allele will be 0.96.
-r_methylated_mother
Ratio of the mother-specific methylation rate. Methylation rate for the maternal allele at a CpG will be r_methylated_mother*p, where p is the methylation rate for the CpG from the profile.